منابع مشابه
Pharmacogenomics and the Failing Heart
n Samuel Beckett’s play, Waiting for Godot, the characters ait by a country roadside for a person named Godot, who ever arrives (1). Godot’s conspicuous absence throughout he play has fostered a variety of different religious, philoophical, and psychoanalytical interpretations, and has led o the use of the phrase “waiting for Godot” as an expression or waiting for someone or something that will...
متن کاملO12: The Heart and the Brain: Stroke Induced Heart Damage
Cardiac diseases are common post-stroke and are associated with increased morbidity and mortality. One possible mechanism of acute cardiac injury is the neurogenic myocardial damage, where the cerebral injury is disturbing the normal sympathetic and parasympathetic neuronal outflow to the heart leading to cardiac damage including myocardial infarctions. The exact mechanism is not completely und...
متن کاملMyocardial Recovery and the Failing Heart
Medical and device therapies that reduce heart failure morbidity and mortality also lead to decreased left ventricular volume and mass and a more normal elliptical shape of the ventricle. These are due to changes in myocyte size, structure, and organization that have been referred to collectively as reverse remodeling. Moreover, there are subsets of patients whose hearts have undergone reverse ...
متن کاملMyocytes From Failing Human Heart
Background—We have observed direct (noncatecholamine-blocking) negative inotropic effects of the selective 2adrenoceptor (AR) antagonist ICI 118,551 in myocytes from failing human ventricle. In this study we characterize the effect in parallel in human myocytes and in myocytes from animal models where 2ARs or Gi proteins are overexpressed. Methods and Results—Enzymatically isolated, superfused ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2016
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.116.022141